High uric acid: not gout "patent".

<p> high uric acid: not gout "patent" <wbr> <wbr> experts advise: cardiac distress alert <wbr> <wbr> <wbr> <wbr> <wbr> <wbr> <wbr> People's Hospital of Guangxi Zhuang Autonomous Region .Nephrology, Chief Physician Xu Biyun <wbr> <wbr> <wbr> "high uric acid to what?" <wbr> <wbr> <wbr> "gout." <wbr> <wbr> <wbr> many people believe that this is the answer .Indeed, gout, high uric acid is the culprit, but the latest study found that high uric acid is not only related to the kidney, but also involving the heart and cardiovascular disease as an "accomplice." .Thus, increased uric acid control is essential. .<wbr> <wbr> <wbr> uric acid from purine <wbr> <wbr> <wbr> people eat the meat, seafood, animal offal, and likely to drink beer, concentrated broth so called purine-rich .substance reacts in the body of purine and eventually produce uric acid. .<wbr> <wbr> <wbr> too much uric acid in addition to increased consumption of purine-rich foods, strenuous exercise, people with cancer, myeloproliferative disorders, acute myocardial infarction and other relevant, but also with the age, gender, geographical distribution, .racial, genetic and social status have a certain relationship. .<wbr> <wbr> <wbr> high uric acid can also endanger the heart <wbr> <wbr> <wbr> high uric acid will have the following two major hazards. .<wbr> <wbr> <wbr> aggravate renal damage is closely related to uric acid and kidney disease, once increased, can lead to urate nephropathy (gouty nephropathy), uric acid nephropathy and renal diseases 3, initiation, increase kidney damage .. .<wbr> <wbr> <wbr> cause coronary heart disease studies have shown that uric acid is increased in patients with coronary heart disease (especially women) were independent risk factors of death, blood uric acid is increased by 59.5 micro mol / L, coronary heart disease risk of death to .48% increase uric acid> 357 micro mol / L were more prone to coronary heart disease; uric acid> 565 micro mol / L was significantly associated with mortality in heart failure, and higher uric acid levels, increased mortality in patients with heart failure, the more apparent. .<wbr> <wbr> <wbr> lifestyle is the treatment of the core <wbr> <wbr> <wbr> usually focus on improving the lifestyle is the treatment of uric acid as the core, including healthy eating, quit smoking, adhere to the exercise and weight control. .For existing gout, uric acid, cardiovascular disease risk factors (such as hypertension, dyslipidemia), and the elderly, low-purine diet should be food-based, strict control of meat, seafood, animal offal high .purine food intake; ensure that the daily volume of 1500 ml or more water, quit smoking, ban beer and liquor; daily moderate-intensity exercise for 30 minutes or more; obesity should control their weight and body mass index (BMI) less than control in 24. .In addition, should avoid prolonged use can lead to increased serum uric acid drugs (such as some antihypertensive drugs including diuretics, etc.). .<wbr> <wbr> <wbr> following uric acid lowering drug therapy should be used: ① uric acid with cardiovascular risk factors, and serum uric acid> 471 micro mol / L in patients; ② no complications, but uric acid> 530 .micro mol / L in patients; ③ of gouty arthritis gout patients; ④ stones gout; ⑤ associated with diabetes or hypertension. .Ideal blood uric acid concentration should be controlled at 357 micro mol / liter. .<wbr> <wbr> <wbr> uric acid lowering drugs are drugs that increase uric acid excretion of uric acid formation and reduction of two major categories of drugs. .<wbr> <wbr> <wbr> increase in uric acid excretion categories: including benzbromarone (Li-Ghali cents), probenecid, methyl pyridine ketones, which applies only to the latter two with normal renal function in patients with elevated uric acid ., while the former can be used for some of renal dysfunction (creatinine clearance> 20 ml / min). .Benzbromarone film is to promote uric acid excretion of drug, and its onset time and efficacy is superior to allopurinol, usually 6 to 8 days after taking the majority of patients return to normal uric acid, serum uric acid level can adhere to medication remained stable .status, security, sound, and antihypertensive drugs, hypoglycemic agents and lipid-free drug interactions between drugs, is only suitable for patients with renal dysfunction medication. .<wbr> <wbr> <wbr> benzbromarone used as follows: adult starting dose is 50 mg / time, 1 day, 1 to 3 weeks after dose adjustment based on serum uric acid level to 100 mg / day, breakfast .after the taking. .Renal insufficiency (creatinine clearance rate "60 ml / min), recommended dose is 50 mg / time, day 1. .Should take note: ① application required urine alkalinization (optional sodium bicarbonate, 3 to 6 grams a day, orally 3 times), in particular, renal dysfunction, should pay attention to regular monitoring of the morning for the first time urinary .pH, to remain at 6.2 ~ 6.9 (more than 7 easily lead to stone), while ensuring that the daily water intake of 1500 ml or more; ② attention to monitoring renal function; ③ disabled patients with uric acid stones. .<wbr> <wbr> <wbr> reduce uric acid categories: drugs allopurinol on behalf of its conventional usage is: adult initial dose of 50 mg / time, 1 or 2 times a day, daily increments of 50 ~ 100 .mg, serum uric acid to recover to 357 micro mol / liter gradually reduce, with the minimum effective dose to maintain a long time. .When the decline in renal function (creatinine clearance rate of "60 ml / min), recommended dose of allopurinol of 50 to 100 mg / day, creatinine clearance <15 ml / time-sharing is disabled. .<wbr> <wbr> <wbr> allopurinol allergy common adverse events were mild allergies (such as rash) can be desensitization therapy, severe allergies (delayed vasculitis, exfoliative dermatitis) often lethal, .disabled. .Medication should be checked regularly during the liver and kidney function, blood routine. .Severe liver and kidney dysfunction, and significantly lower blood cells were disabled. .</ P> <p> see the original "Family Health News" March 8, 2011 6th edition "concerned about elderly patients" </ P>.